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In angiosperms, successful sexual reproduction relies on complicated communications between male and female organs. We previously disclose a molecular gating mechanism in which distinct peptide classes from pollen PCP-B peptides compete with stigma RALF peptides for interaction with a stigmatic receptor kinase complex, repressing the stigmatic ROS generation and allowing the pollen to hydrate and germinate. Through PCP-Bγ-induced phosphoproteomic and functional studies of the downstream pathways, we found that PCP-Bs trigger FER/ANJ-receptor controlled compatible responses, particularly the opening of aquaporins via H+-ATPase-mediated pH changes, thereby facilitating pollen hydration. Moreover, we found that the PP2C phosphatases act as negative regulators of FER kinase activity, thereby modulating ROS accumulation in the stigma. Exploring downstream signaling of CrRLK1L–ROS pathway, we found that auxin activates the FER–ROS pathway in root hair cells, results in the oxidative modifications of TIR1/AFB2 and in turn their transport from cytoplasm to nucleus for transcriptional auxin responses.  Furthermore, we developed a small-molecule inhibitor that specifically disrupts FER kinase activity, namely FRV. Assisted by the FRV tool and quantitative phosphoproteomics, we characterized a series of signaling pathways and network regulated by RALF1 and FER, which leads to apoplastic alkalinization and regulates cell expansion in root meristem. Given the conservation of FRV binding sites in FER proteins across land plant species, FRV could serve as valuable tool for dissecting FER signaling mechanisms as well as facilitating agricultural applications.

李超博士，華東師范大學生命科學學院二級教授、植物學科主任、現代農業科學與技術研究所所長。獲國家自然科學基金杰青、重點項目、上海市青年英才計劃拔尖項目、中國植物生理與植物分子生物學學會“衛志明青年創新獎”和上海生化學會“青年新銳獎”等。2002年于中國農業大學獲學士學位，同年進入中科院遺傳與發育生物學研究所碩博連讀，2005-2008年在北京生命科學研究所聯合培養，2008年獲博士學位后到美國馬薩諸塞大學開展博士后研究。2016年回國在華東師范大學工作至今，圍繞小肽-受體激酶調控植物發育的分子機理開展研究，主要成果發表在Science、Dev Cell、Mol Plant、PNAS、eLife等國際知名期刊。